There was this part in "Once Upon a Time in Mexico" where Antonio Banderas slipped under this guy with his guns pointed at the guys crotch and he says (in Spanish) "What do you want in Life?"
Here are some good ones from some movies made by Happy Madison Productions..
Grandma: Sir, can I trouble you for a warm glass of milk? It helps me go to sleep.
Orderly: You can trouble me for a warm glass of shut-the-hell-up! Now, you will go to sleep or I will put you to sleep. You're in my world now, grandma.
McGavin: I eat pieces of shit like you for breakfast!
Gilmore: You eat pieces of shit for breakfast?!
Gilmore To Bob Barker: The price is wrong, bitch.
These is from Billy Madison:
Sandler: Heey, Carl..Good to see you!
Chris Farley- NO YELLING ON THE BUS!
Principal- Everyone in this room is dumber after hearing you speak.