Nope. The mana regen granted by Trang's Partial set helps out a bit, plus my Pickit keeps me stocked with rejuvs.

I use some other skills occasionally, like when I hit a large group of the skeletons. I'll usually amp and Corpse Explode a bit to speed things up, or if I hit a Mana-Burn group, I'll keep them off me with a Bone Wall or two.

Edit: Damage update. I now have 2x Poison Facet (both are +5% dmg) and my Poison Nova now does 7.4k, and my Poison Explosion is over 63k.